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Apolipoprotein Mimetics in the Management of Human Disease

Tác giả: Anantharamaiah, G M .; Goldberg, Dennis

Chủ đề:

Chủ đề: Medicine; Human Disease

Nhà xuất bản: Adis

Năm xuất bản: 2015

Loại tài liệu: Book

Mô tả vật lý: 200 p.

Định danh: 978-3-319-17350-4

Ngôn ngữ: en

Đọc trực tuyến

The book also presents novel ideas, highly unexpected mechanisms of action in animal models and even in initial clinical studies in humans, which can lead to additional improvements in basic and clinical research in biological science. All the chapters are written by experts in their respective fields who have contributed immensely to the literature. This is the first compendium of this growing field presented in the form of a book.

Cover
Half-title pages
Title pages
Copyright
Preface
Abbreviations
Contents
Introduction
- The Structure and Function of Apolipoprotein Mimetic Peptides
- Bibliography
The Editors
HDL and the Amphipathic Helix
- Discovery, Isolation, and Characterization of HDL
- Early History of HDL Structure
- Discovery of the Amphipathic Helix: An Untold Story
- The Amphipathic Helix and HDL
- Current History of HDL Structure
- Current Thoughts on the Biomedical Implications of HDL
- References
- What Are Peptide Mimetics and Should I Care?
ApoA-I Mimetic Peptides: A Review of the Present Status
- ApoA-I Mimetic Peptides Were Designed to Mimic a Plasma Apolipoprotein
- The Peptides Were Effective in a Large Number of Animal Models of Disease
- Reconciling the Divergent Results from the Clinical Trials
- The 4F Peptide Was Tested in Human Clinical Trials
- Determining the Mechanism of Action of Oral ApoA-I Mimetic Peptides
- Overcoming the Barrier of the High Cost of Production of Chemically Synthesized ApoA-I Mimetic Peptides
- Other Peptides
- Conclusions
- References
Apolipoprotein Mimetic Peptides for Stimulating Cholesterol Efflux
- Introduction
- Reverse Cholesterol Transport Pathway
- Apolipoprotein Mimetic Peptides
  - ESP24218 Peptide
  - D-4F Peptide
  - L-4F Peptide
  - Retroinverso Peptides
  - 5A Peptide
  - ATI-5261 Peptide
- References
- Summary
ApoA-I Mimetic Peptides and Diabetes
- 4F Background
- Introduction
- 4F and Diabetes
- Conclusion
- References
Apolipoprotein A-I Mimetic Peptides in Mouse Models of Cancer
- Inflammation and Lipoproteins in Cancer
- Introduction
- ApoA-I and Ovarian Cancer
- ApoA-I Mimetic Peptides as Cancer Therapeutics
- ApoA-I Mimetic Peptides and Colon Cancer
- Conclusions
- References
Effects of ApoA-I Mimetic Peptide L-4F in LPS-Mediated Inflammation
- Introduction
- HDL and LPS
- LPS and Sepsis
- ApoA-I and Sepsis
- ApoA-I Mimetic Peptides 18A and 4F
- ApoA-I Mimetic Peptide L-4F and LPS
- ApoA-I Mimetic Peptide L-4F in Polymicrobial Septic Models
- Efficacy of L-4F in Different Models of Atherosclerosis and Metabolic Syndrome (Diabetes) Could Be in Part Accounted for by Its Anti-endotoxin Property
- References
Apolipoprotein Mimetics in the Amelioration of Respiratory Inflammation
- Introduction
- Genetic Deletion of ApoA-I
- 4F Inhibits Airway Inflammation
- Potential Mechanisms of Action
- Novel Apolipoprotein Mimetics
- Other Apolipoprotein Mimetics That Modulate Airway Inflammation
- References
Regulation of Macrophage Polarity by HDL, Apolipoproteins, and Apolipoprotein Mimetic Peptides
- Introduction
- Macrophage Polarization
- Macrophage Heterogeneity and Atherosclerosis
- HDL Composition and Function
- Dysfunctional HDL
- HDL-Associated S1P and Macrophage Phenotype
- ABCA1 and Macrophage Polarization
- HDL, Activating Transcription Factor, and Macrophage Polarization
- Apolipoprotein A-I Mimetic Peptide Design
- Apolipoprotein A-I Mimetics and Macrophage Phenotype
- Cellular Bioenergetics and Macrophage Phenotype
- Summary
- References
Apolipoprotein E and Atherosclerosis: Beyond Lipid Effects
- ApoE and Atherosclerosis
  - ApoE and Lipid Homeostasis in Cells of the Hematopoietic System
  - ApoE and Plasma Lipid Homeostasis
  - ApoE Regulation of Macrophage Polarity and Inflammatory Phenotypes
  - Pleiotropic Properties of ApoE in Atherosclerosis
  - ApoE Controls Lipid-Induced Monocytosis
  - ApoE Drives M2 Macrophage Polarization In Vivo
  - Cell-Derived ApoE Controls Lipid-Induced HSPC Proliferation via ABCA-1/ABCG-1
  - Plasma ApoE Reduces Neutral Lipids and Activation of Monocytes in Spontaneously Hyperlipidemic Mice
  - ApoE Increases ApoA-I HDL and Improves Their Function in Hyperlipidemia
  - ApoE4 Domain Interaction and Atherosclerosis
  - Spontaneous and Diet-Induced Hyperlipidemia: Impact on Lipoprotein Biology and Atherosclerosis
  - ApoE Regulation of Myeloid Cells via MicroRNA: Impact on Atherosclerosis
- Conclusion
- References
Apolipoprotein E Mimetic Peptides: Cholesterol-Dependent and Cholesterol-Independent Properties
- Current Approaches to Cholesterol Reduction
- Studies of Cationic Domain Peptides
- Ac-hE18A-NH2
  - Design
  - Initial Studies and Mechanism of Plasma Cholesterol Clearance
  - Effects on Plasma Cholesterol in WHHL and Cholesterol-Fed Rabbits
  - Atheroprotective Properties
  - Reduction of Oxidative Processes
  - Sustained Effects
  - Comparisons with Other Peptides
  - Alzheimers Disease
  - Modes of Administration
- Ac-hE18A-NH2 Clinical Studies: LPX-112
- Conclusions
- References
Apolipoprotein E and Mimetics as Targets and Therapeutics for Alzheimer’s Disease
- Introduction
- Peptides as Mimetics of Holo-ApoE Proteins
- ApoE-Mimetic Peptides Cross the BBB
- ApoE Has an Anti-inflammatory Activity in Humans
- The Anti-inflammatory Activity Ex Vivo in Peritoneal Macrophages Is Dependent on ApoE Genotype
- APOE Regulates Neurite Outgrowth
- COG112/COG1410 as Supplementation Therapy for Tg2576/NOS2 Knockout Alzheimer’s Mice
- Phosphorylated Tau and Neurofibrillary Tangles
- Neuronal Loss
- Behavioral Deficits
- Conclusions
- References