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Epilepsy and Brain Tumors

Tác giả: Newton, Herbert B.; Maschio, Marta

Chủ đề:

Chủ đề: Medicine; Epilepsy; Brain Tumors

Nhà xuất bản: Academic Press

Năm xuất bản: 2015

Loại tài liệu: Book

Mô tả vật lý: 272 p.

Định danh: 978-0-12-417043-8

Ngôn ngữ: en

Đọc trực tuyến

Includes coverage of epidemiology, pathology and treatment of both primary and metastatic brain tumors; Offers additional insight into supportive care, incidence in children, focal epileptogenesis, clinical evaluation, antiepileptic drugs, surgical treatment, cognitive rehabilitation, and more; Chapters authored and edited by leaders in the field around the globe – the broadest, most expert coverage available

Cover
Half-title pages
Title pages
Copyright
Dedication
Foreword
Preface
Contributors
Brain Tumor-Related Epilepsy: Introduction and Overview
- Introduction
- Epilepsy: Definition, Incidence, Social Context and Treatment Options
  - Epilepsy in the Context of BTs: Epidemiology and Incidence
  - Detection, Classification, and Documentation of Seizures
  - The Unique Role of Epileptogenesis and Drug Resistance in BTRE
    - Pharmacoresistance
  - QoL in BTRE Patients
  - Impact of AEDs in BTRE Patients
  - Health Economics and BTRE
  - Neurocognitive Evaluation and Possible Rehabilitative Programs
- References
Overview of Epidemiology, Pathology, and Treatment of Primary Brain Tumors
- Epidemiology of PBT
- Pathology of Selected PBT
  - Diffuse Astrocytomas
  - Localized Astrocytomas
  - Medulloblastoma and Other Embryonal Tumors
  - Oligodendrogliomas and Oligoastrocytomas
  - Meningioma and Other Tumors of the Meninges
  - Primary Central Nervous System Lymphoma
- Surgical Therapy of PBT
- Chemotherapy of PBT
- Radiation Therapy of PBT
- Molecular or "Targeted" Treatment
- Acknowledgments
- References
Overview of Epidemiology, Pathology, and Treatment of Metastatic Brain Tumors
- Epidemiology of MBTs
- Pathology of MBTs
- Surgical Therapy of MBTs
- Radiation Therapy of MBTs
- Chemotherapy of MBTs
- Acknowledgments
- References
Supportive Care of Brain Tumor Patients
- Introduction
- Seizures and Anticonvulsant Therapy
- Corticosteroids
- Gastric Acid Inhibitors
- Thromboembolic Complications and Anticoagulation
- Dysphagia and Swallowing Disorders
- Psychiatric Issues
- Pain Control Issues
- Palliative Care
- Ethical Issues
- Conclusion
- References
Brain-Tumor-Related Epilepsy in Children
- Epilepsy-Associated Brain Tumors
- The Pediatric Perspective
- Pathophysiology
- Epidemiology
  - Brain Tumors
  - Seizures and Epilepsy
- Presentation
  - Brain Tumors
  - Seizures and Epilepsy
- General Principles of Management
- History and Physical Exam
- Diagnostic Evaluation
  - Scalp EEG
  - Intracranial EEG
  - MRI
  - Other Imaging Studies
  - Genetics
  - Magnetic and Electrical Source Localization
  - Neuropsychological Assessment and Other Studies Used to Localize Eloquent Brain
  - Tissue Diagnosis and Molecular Tumor Markers
- Medical Management
  - Anticipatory Guidance
  - Maintenance Antiseizure Drugs
  - Rescue Antiseizure Drugs
  - Role of Antiseizure Drugs in Children Without a History of Seizures
  - Chemotherapy, Biologic Agents, and Steroids
  - Dietary Considerations and Alternative Therapies
- Surgical Management
  - Goals and Approaches
  - Timing of Surgical Resection
  - Lesionectomy Tumorectomy Versus Lesionectomy " Plus"
  - Palliative Strategies
- Outcome
- Future Directions
- Acknowledgment
- References
Mechanisms of Focal Epileptogenesis
- Time Course and Specificity of Acquired Epileptogenesis
- References
Pathophysiology of Brain Tumor-Related Epilepsy
- Chapter Contents
- Epidemiology of BTRE
- Introduction
- Pathophysiology of BTRE
- Treatment of BTRE
- References
The Neurophysiology of Central Nervous System Tumors
- Introduction
- EEG Modalities and Applications
- EEG Background Changes
- Epileptiform Activity
- Meningiomas
- Generation of Abnormal Cerebral Activity
- References
Surgical Treatment for Epilepsy
- Evaluation and Selection of the Surgical Candidate
- Introduction
- Resection Procedures
  - Common Complications
  - Extra-temporal Cortical Resections
  - Temporal Lobectomy
  - Hemispherectomy
- Nonresective Techniques
- Disconnection Surgeries
  - Corpus Callosotomy
  - Multiple Subpial Transections
  - Vagal Nerve Stimulation
  - Deep Brain Stimulation
  - Responsive Neurostimulation
- References
Clinical Evaluation of Epilepsy in the Brain-Tumor Patient
- Differential Diagnosis
- Clinical History and Physical Examination
- Neuroimaging Evaluation
- Clinical and Electrophysiological Work-Up
- Effects of Oncological Therapy on Brain Tumor-Related Epilepsy
- References
Antiepileptic Drugs:
- Carbamazepine
- Ethosuximide
- Phenobarbital
- Phenytoin
- Primidone
- Valproate
- References
Antiepileptic Drugs: Second and Third Generation
- Clobazam
- Introduction
- Eslicarbazepine Acetate
- Ezogabine/Retigabine
- Felbamate
- Gabapentin
- Lacosamide
- Lamotrigine
- Levetiracetam
- Oxcarbazepine
- Perampanel
- Pregabalin
- Rufinamide
- Tiagabine Hydrochloride
- Topiramate
- Vigabatrin
- Zonisamide
- References
Antiepileptic Drugs and Brain Tumor Patients
- Introduction
- Pathophysiology
- Type of Seizure
- Treatment of Seizures
  - First-Generation AEDs
  - Newer AEDs
- Levetiracetam
- Oxcarbazepine
- Lacosamide
- Pregabalin
- Topiramate
- Zonisamide
- Conclusion
- Lamotrigine
- References
Clinical Approach to Brain Tumor-Related Epilepsy
- Seizure Prophylaxis in Patients with BTRE
- Is There a Best Practice for Seizure Treatment?
  - Drug Resistance and Epileptogenicity
  - Introduction
  - Use of Systemic Treatment for Seizure Control
  - Use of AEDs as Antineoplastic Treatment
  - Adverse Events Specific to BTRE Patients
  - Efficacy of AEDs on BTRE: An Overview
  - Impact of AED Therapies on Cognition
  - Potential Interactions with Systemic Treatments
  - How to Choose an AED?
  - Impact of AED Therapies on QoL
  - Is It Possible to Stop an AED in BTRE, and When?
- Clinical Approach to BTRE
- Driving and BTRE
- References
Neuropsychology of BTRE
- Introduction
- Overview of Neurocognitive Impairment in BT, Epilepsy, and BTRE
  - Neurocognitive Impairment in BT
  - Neurocognitive Impairment in Epilepsy
- Neurocognitive Impairment in BTRE
- Specific Cognitive Deficits in BT, Epilepsy, and BTRE
  - Specific Cognitive Deficits in BT
  - Specific Cognitive Deficits in Epilepsy
  - Specific Cognitive Deficits in BTRE
- Overview of Neuropsychological Assessment Techniques for BT, Epilepsy, and BTRE
  - Neuropsychological Assessment Techniques for BT
  - Neuropsychological Assessment Techniques for Epilepsy
  - Neuropsychological Assessment Techniques for BTRE
- Psychological Issues in BT, Epilepsy, and BTRE
  - Psychological Issues in BT
  - Psychological Issues in Epilepsy
  - Psychological Issues in BTRE
- Sexual Disturbances in Patients with BT, Epilepsy and BTRE
  - Sexual Disturbances in Patients with BT
  - Sexual Disturbances in Patients with BTRE
  - Sexual Disturbances in Patients with Epilepsy
- QoL Assessment and Monitoring in BT, Epilepsy and BTRE
  - QoL Assessment and Monitoring in BT
  - QoL Assessment and Monitoring in Epilepsy
  - QoL Assessment and Monitoring in BTRE
- Conclusions
- References
Cognitive Rehabilitation in Patients with BTRE
- Introduction
- Goals of Cognitive Rehabilitation
- Treatment Modalities in BT
- Treatment Modalities in Epilepsy
- Pharmacological Approaches for Treatment of Cognitive Deficits
- Treatment Modalities in BTRE
- Caregivers Issues
- Implications for Future Research in BTRE
- References
Social Cost of Brain Tumor-Related Epilepsy
- Introduction
- Health Economic Reporting: Terminology and Aims
- Health Economics: Funding Priorities
  - BTRE: Economic Burden Within the Context of Neurological Disease
  - Health Technology Assessment
- Epilepsy
- Brain Tumor
- Conclusion
- References
The Prospects of Brain Research within Horizon 2020: Responding Efficiently to Europes Societal Needs ...
- Summary
Index