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Mechanisms of Gene Regulation.

Tác giả: Carlberg, Carsten; Molnár, Ferdinand

Chủ đề:

Chủ đề: Medicine; Biomedical sciences; Gene Regulation

Nhà xuất bản: Springer

Năm xuất bản: 2014

Loại tài liệu: Book

Mô tả vật lý: 214 p.

Định danh: 978-94-007-7905-1

Ngôn ngữ: vi

Đọc trực tuyến

Tải tài liệu

Preface
Cover
Title page
Acknowledgements
Contents
List of Abbreviations
Part I. Introduction
- Chapter-1. Overview: What Is Gene Expression?
  - Overview: What Is Gene Expression?
    - 1.1 The Central Dogma of Molecular Biology
    - 1.2 Transcriptional Complexity of Genes
    - 1.3 Elements of Transcriptional Regulation
    - 1.4 The Role of Chromatin Activity in Gene Regulation
    - 1.5 Gene Expression Programs
    - 1.6 Key Concepts
    - Further Reading
- Chapter-2. The Impact of Chromatin
  - The Impact of Chromatin
    - 2.1 Eu- and Heterochromatin
    - 2.2 Nucleosomes
    - 2.3 Histone Modifications in Chromatin Opening and Closing
    - 2.4 Genomic Effects of Histone Modifications
    - 2.5 Chromatin Architecture
    - 2.6 Impact of Epigenetic Signaling in Health and Disease
    - 2.7 Key Concepts
    - Further Reading
Part II. Transcription Factor View
- Chapter-3. The Basal Transcriptional Machinery
  - The Basal Transcriptional Machinery
    - 3.1 The Core Promoter
    - 3.2 The TATA Box
    - 3.3 Core Promoter Elements
    - 3.4 TFIID as a Paradigm of a Multi-Protein Complex
    - 3.5 Genome-Wide Approaches on Core Promoter Identification
    - 3.6 The Mediator Complex
    - 3.7 Key Concepts
    - Further Reading
- Chapter-4. Transcription Factors
  - Transcription Factors
    - 4.1 Site-Specific Transcription Factors
    - 4.2 Transcription Factor Domains
    - 4.3 Dimeric Transcription Factor Complexes: The Example of Nuclear Receptor Heterodimers
    - 4.4 Bioinformatic Identification of Transcription Factor-Binding Sites
    - 4.5 Transcription Factor Expression Profile
    - 4.6 Classification of Transcription Factors
    - 4.7 Key Concepts
    - Further Reading
- Chapter-5. Linking Signal Transduction and Gene Regulation
  - Linking Signal Transduction and Gene Regulation
    - 5.1 Activation of Latent Transcription Factors
    - 5.2 Transcription Factor Networks
    - 5.3 Programming Cellular Differentiation by Transcription Factors
    - 5.4 NFKB Signaling
    - 5.5 Transcription Factors in the Inflammatory Response
    - 5.6 Sensing Cellular Stress: The p53 Pathway
    - 5.7 Key Concepts
    - Further Reading
- Chapter-6. Switching Genes on and off: The Example of Nuclear Receptors
  - Switching Genes on and off: The Example of Nuclear Receptors
    - 6.1 The Nuclear Receptor Superfamily
    - 6.2 Molecular Interactions of Nuclear Receptors
    - 6.3 Physiological Role of Nuclear Receptors
    - 6.4 Nuclear Receptors and Their Ligands
    - 6.5 Interaction of Nuclear Receptors with Co-Factors
    - 6.6 Key Concepts
    - Further Reading
- Chapter-7. Mapping the Genome
  - Mapping the Genome
    - 7.1 Phylogenetic Footprinting
    - 7.2 The ENCODE Project
    - 7.3 Exploring Data of the ENCODE Project
    - 7.4 Integrating ChIP-seq Data
    - 7.5 Alternative DNA-Binding Modes of Transcription Factors
    - 7.6 Assigning Transcription Factors to Their Target Genes
    - 7.7 Key Concepts
    - Further Reading
Part III. Chromatin View
- Chapter-8. Chromatin Modifiers
  - Chromatin Modifiers
    - 8.1 The Histone Code Model
    - 8.2 Histone Modifying Enzymes
    - 8.3 Genome-Wide Analysis of Histone Markers and Their Modifying Enzymes
    - 8.4 Chromatin Modifiers in Disease
    - 8.5 Key Concepts
    - Further Reading
- Chapter-9. Genomic Imprinting
  - Genomic Imprinting
    - 9.3 Genomic Imprinting
    - 9.4 Models of Insulator Function
    - 9.5 Heritance of CTCF-Mediated Chromatin Structures
    - 9.6 Key Concepts
    - Further Reading
    - 9.1 Insulators
    - 9.2 The Genome Regulator CTCF
- Chapter-10. The Epigenome
  - The Epigenome
    - 10.1 DNA Methylation
    - 10.2 DNA Methylation on the Genome Scale
    - 10.3 DNA Methylation, Heterochromatin and Gene Silencing
    - 10.4 Epigenomics in Health and Disease
    - 10.5 Key Concepts
    - Further Reading
- Chapter-11. Chromatin Remodeling
  - Chromatin Remodeling
    - 11.1 The Impact of Chromatin Remodeling
    - 11.2 ATP-Dependent Remodeling Complexes
    - 11.3 Nucleosome Positioning at Promoters
    - 11.4 Pioneer Factors
    - 11.5 Transcriptional Dynamics and Noise
    - 11.6 Key Concepts
    - Further Reading
- Chapter-12. Chromatin Architecture
  - Chromatin Architecture
    - 12.1 Organization of the Nucleus
    - 12.2 Larger Order DNA Loop Formation
    - 12.3 Compartmentalization of Nuclear Processes
    - 12.4 Transcription Factories
    - 12.5 Nuclear Positioning and Disease
    - 12.6 Key Concepts
    - Further Reading
Part IV. Non-Coding RNA View
- Chapter-13. Regulatory RNA
  - Regulatory RNA
    - 13.1 Non-coding RNAs
    - 13.2 miRNAs and their Function
    - 13.3 Long ncRNA
    - 13.4 eRNAs
    - 13.5 Gene Regulation by miRNAs and Transcription Factors
    - 13.6 Key Concepts
    - Further Reading