Chapter 1 Gerald Reaven and the Discovery of Syndrome X
Chapter 2 Factors that Contribute to Metabolic Syndrome
Carbohydrates and the Glycemic Index
Fatty Acids and how they Differ
Chapter 3 The Pathophysiology of Metabolic Syndrome
Insulin Resistance and Compensatory Hyperinsulinemia
The Rise of the Adipocyte
Adipocytes, Insulin, and Metabolic Syndrome
The Liver, Fat, and Insulin Resistance
Non-alcoholic Fatty Liver Disease
Hormonal Interactions in the Liver
Peroxisome Proliferation Activating Receptors
Asymmetrical Dimethylarginine
Chapter 4 Metabolic Syndrome and Psychiatric Illness
Insulin Resistance and Major Depression
The Liver, Metabolic Syndrome and Major Depression
Seasonal Affective Disorder
Bipolar Affective Disorder
Metabolic Syndrome, Schizophrenia, and the NMDA Receptor
Chapter 5 Psychiatric Medications and Metabolic Syndrome
Atypical Antipsychotics and Weight Gain
Genetics and Atypical Antipsychotic-induced Weight Gain
Mechanisms of Atypical Antipsychotic-induced Weight Gain
Atypical Antipsychotics and Insulin Resistance
Effects of Atypical Antipsychotics on Serum Lipids
Atypical Antipsychotics and Diabetes
Guidelines for Monitoring Patients on Atypical Antipsychotics
Add-on Treatments to Counter Weight Gain and Metabolic Syndrome
Difficult Choices Must be Made
Chapter 6 Depression, Metabolic Syndrome, and Heart Disease
Ischemic Heart Disease and Myocardial Infarction
Does Treating Major Depression Reduce Cardiac Risk?
Chapter 7 Metabolic Syndrome, Insulin and Alzheimers Disease
The Stages of Alzheimers Disease
Insulin and Alzheimers Disease
Insulin-Degrading Enzyme and Amyloid
Inflammation and Alzheimers Disease
Chapter 8 Metabolic Syndrome, Sleep, and Sex
Sleep Apnea, Stress, and Metabolic Syndrome
Smuggling, Snoring and the Velopharynx
Sleep, Mood and Glycogen Synthase Kinase-3 (GSK-3)
Sleep Apnea and Alzheimers Disease
Inadequate Sleep and Altered Sleep Schedules
Metabolic Syndrome and Sex
Chapter 9 Diets for Weight Loss and Metabolic Syndrome
Low-Fat, High-Carbohydrate Diets
A Few Words about Protein
Diet, Appetite, and Satiety
Gerald Reavens Syndrome X Diet
Other Low-Carbohydrate Diets
Chapter 10 Nutritional Supplements and Metabolic Syndrome
Fish Oil (Omega-3 Fatty Acids, EPA, DHA)
Niacin (Nicotinic Acid, Vitamin B3)
S-adenosylmethionine (SAMe)
Chapter 11 Conclusion: Metabolic Syndrome and what to do about it
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