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Neural Stem Cells in Development, Adulthood and Disease

Tác giả: Kuhn, H. Georg; Eisch, Amelia J.

Chủ đề:

Chủ đề: Medicine; Cell

Nhà xuất bản: Humana Press

Năm xuất bản: 2015

Loại tài liệu: Book

Mô tả vật lý: 214 p.

Định danh: 978-1-4939-1908-6

Ngôn ngữ: en

Liên kết: Stem Cell Biology and Regenerative Medicine;

Đọc trực tuyến

Tải tài liệu

This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others.

Cover
Stem Cell Biology and Regenerative Medicine
Title pages
Preface
Acknowledgments
Contents
Contributors
List of Abbreviations
Adult Neurogenesis and Regeneration: Focus on Nonmammalian Vertebrates
- The Neurogenic Niches
- Adult Neurogenesis in Nonmammalian Amniotes
- Adult Neurogenesis in Lower Vertebrates
  - Amphibians
  - Fish and Lamprey
- Conclusions
- References
Differential Intrinsic and Extrinsic Regulations of the Two Adult Neurogenic Regions
- Introduction
- Neural Stem Cells and Neurogenesis
  - Neural Stem Cells in Developmental and Adult Brains
  - Neurogenesis in Adults
- Differences Between SGZ and SVZ Neurogenesis
  - Different Neurogenic Destinations
  - Different Neurogenic Niches
  - Distinct Response to Stimuli
  - Distinct Response to Pathological Conditions
  - Different Intrinsic Characteristics
- Molecular Mechanism Underlying Differences Between SGZ and SVZ Neurogenesis
  - Extrinsic Factors
    - Ependymal Cell Niche
    - Astrocyte Niche
    - Neuronal Circuitry
    - Vascular Niche
  - Intrinsic Genetic and Epigenetic Controls
    - Transcriptional Regulation
    - Epigenetic Machinery
    - Posttranscriptional Regulation
- Summary
- References
The Role of Adult-Born Dentate Granule Neurons in the Regulation of Mood
- Adult-Born Dentate Granule Neurons and Pattern Separation
- Adult-Born Dentate Granule Neurons and Mood Regulation
- Discussion
- References
Stem Cells and Neurogenesis in Relation to Dementia and Alzheimers Disease Mouse Models
- Introduction
- Hippocampal Neurogenesis
- Regulation of Neurogenesis
- Regulation of Plasticity by Disease
- Cell Cycle Markers in the Alzheimer Brain
- Cellular Plasticity and Neurogenesis in the Human and Alzheimer Brain
- Neurogenesis and AD Mouse Models
- Amyloid Precursor Protein Transgenic Mice
- Presenilin 1 Transgenic Mice
- APP/PS Bigenic Mice
- Tau Transgenics
- Environmental Stimulation of Neurogenesis in AD Models
- Preventive Strategies for AD
- References
Hippocampal Neurogenesis in Neurodegenerative Movement Disorders
- Introduction
- Hippocampal Neurogenesis in Parkinson’s Disease
  - Nonmotor Symptoms in PD
  - Cellular Plasticity and Neurogenesis in the Hippocampus of Transgenic Animal Models of PD
  - Hippocampal Neurogenesis in Human PD
  - Possible Underlying Mechanisms of Impaired Hippocampal Neurogenesis in PD
- Interventions for Hippocampal Neurogenesis in PD
- Hippocampal Neurogenesis in Huntington’s Disease
  - Nonmotor Symptoms in HD
  - Hippocampal Neurogenesis in Transgenic Animal Models of HD
  - Hippocampal Neurogenesis in Human HD
  - Mechanisms Underlying Impaired Hippocampal Neurogenesis in HD
- Interventions to Restore Hippocampal Neurogenesis in HD
- Conclusion
- References
Linking Adult Neurogenesis to Epilepsy Through Epigenetics
- Introduction
- Epilepsy and Aberrant Seizure-Induced Hippocampal Neurogenesis
- Epigenetic Regulation of Hippocampal Neurogenesis in Epilepsy
  - DNA Methylation
  - Histone Modifications
  - Noncoding RNAs
- Future Perspectives
- References
Activity-Based Maintenance of Adult Hippocampal Neurogenesis: Maintaining a Potential for Lifelong Plasticity
- References
Neural Stem Cells and Demyelinating Disease
- Functions of the Myelin Sheath
- Demyelination
- Understanding Developmental Myelination and Regenerative Remyelination
- OPC Development in the Forebrain
- Adult OPCs
- Defining Adult OPCs
- Germinal Niches
- The Biology of Remyelination
- The Impact of Aging on Remyelination
- Remyelination Failure
- Enhancing Remyelination
  - Exogenous Therapies
  - Neural Stem Cells
- Oligodendrocyte Precursor Cells
- Olfactory Ensheathing Cells
- Schwann Cells
- Mesenchymal Stem Cells
- Endogenous Therapies
- Conclusions
- References
Stem Cell-Based Therapies for Spinal Cord Regeneration
- Introduction
- Stem Cell Nomenclature
  - Embryonic Stem Cells
  - Adult Neural Stem/Progenitor Cells
  - Fetal Stem Cells
  - Induced Pluripotent Stem Cells
- Therapeutic Targets of Neural Stem Cell Transplantation
  - Remyelination
  - Axonal Regrowth
  - Neuronal Replacement
- Stem Cell Transplantation: Clinical Application
- References
- Summary and Conclusions
Direct Reprogramming of Somatic Cells into Induced Neuronal Cells: Where We Are and Where We Want to Go
- A Brief History of Reprogramming
- From Somatic Cells to Neurons
- Reprogramming Astroglial Cells into Neurons
- The Role of Pro-neural Genes in Reprogramming
- The Dual Role of Ascl1 in CNS Development
- Reprogramming by Noncoding RNAs
- The Impact of the Epigenetic Landscape on Reprogramming
- Deciphering Molecular Mechanisms of Direct Reprogramming
- Improving Reprogramming Efficiency
  - Future Perspectives and Challenges
- Modeling Neurodegenerative Diseases
- Safety Issues Regarding the Use of Induced Neuronal Cells
- The Ultimate Goal: In Vivo Reprogramming for Brain Repair
  - Concluding Remarks
- References
Index