Copyright â 2014 Elsevier
ABC Transporter Regulation by Signaling at the Blood-Brain Barrier: Relevance to Pharmacology
ABC Transporters at the Blood-Brain Barrier
ABC Transporter Regulation
Autonomous transcription factors
Signaling-activated transcription factors
Altered transporter expression in disease
Signals that regulate ABC transporter activity
Regulation of P-glycoprotein activity through signaling
Regulation of P-glycoprotein activity through VEGF signaling
Regulation of BCRP activity through estrogen signaling
Mechanisms underlying reduced ABC transporter activity
P-glycoprotein Trafficking as a Therapeutic Target to Optimize CNS Drug Delivery
Endothelial Cells and the BBB
The BBB/Neurovascular Unit
Transport Across the Brain Barriers
Drug Delivery to the CNS: Strategies Developed to Circumvent Brain Barrier Sites
Inhibition of Brain Barrier Efflux Transporters
Functional Expression of Drug Transporters in Glial Cells: Potential Role on Drug Delivery to the CNS
Physiological Role of the BBB and Brain Parenchymal Cellular Compartments
Functional Expression of Drug Transporters in Glial Cells
ABC drug efflux transporters
Breast cancer resistance protein
Organic anion-transporting polypeptides
Organic anion transporter family
Organic cation transporter systems
Organic cation transporters
Carnitine/cation transporters
Nucleoside membrane transport systems
Concentrative nucleoside transporters
Equilibrative nucleoside transporters
Monocarboxylate transporters
Regulation of Drug Transporters in Glial Cells in the Context of Neuropathologies
Drugs of abuse, analgesics, and anesthetics
Blood
Brain Barrier Na Transporters in Ischemic Stroke
Ion Transporters and Channels of the BBB
Na-K-Cl cotransport of BBB endothelial cells
Na/H exchange of BBB endothelial cells
BBB Na-K-Cl Cotransport and Na/H Exchange in Ischemic Stroke and Cerebral Edema
Effects of ischemic factors on BBB Na-K-Cl cotransporter activity
In vivo studies: Effects of bumetanide on middle cerebral artery occlusion-induced edema and brain Na uptake
Effects of ischemic factors on BBB Na/H exchanger activity
In vivo studies: Effects of HOE642 on MCAO-induced edema and brain Na uptake
Ischemia-induced BBB endothelial cell swelling: Roles of Na-K-Cl cotransport and Na/H exchange
Signaling Mechanisms: Roles of AMP Kinase and p38, JNK and ERK MAP Kinases
Hormonal and Metabolic Factor Effects on BBB Na Transporter Expression and Activities
Estradiol effects on CMEC Na transporters
Hyperglycemia effects on CMEC Na transporters
Transcytosis of Macromolecules at the Blood
Brain Barrier
Endocytosis in Brain Endothelia
Mechanisms of Macromolecule Transcytosis
Vesicle Trafficking and Subcellular Localization in Brain Endothelia
Recycling of Vesicles to Apical or Basolateral Membranes
Targeting Receptor-Mediated Transport for Drug Delivery to Brain
Drug Delivery to the Ischemic Brain
Pathophysiology of Ischemia
Poly(ADP-ribose) polymerase
Reperfusion and immune response
ROS and changes to the BBB
Drug Delivery to the Hypoxic/Ischemic Brain
Organic anion transporting polypeptides
Transporter/substrate interactions at the BBB
Targeting and delivery across the BBB
Delivery of Chemotherapeutics Across the Blood
Brain Barrier: Challenges and Advances
Blood-Brain Barrier Disruption
Delivering agents across the BBB: Preclinical studies
Factors that impact chemotherapy delivery to brain tumors
Preclinical BBBD chemotherapy neurotoxicity studies
The clinical technique of osmotic BBB opening
Safety of BBBD in a multicenter setting
Development and characterization of a CNS lymphoma rat model
mAb delivery and efficacy in the preclinical setting
Therapy studies in the rat CNS lymphoma model
mAb delivery to brain in the clinical setting
Neurocognitive outcomes in long-term PCNSL survivors
Anaplastic oligodendroglioma and CNS embryonal tumors: BBBD outcomes
Preclinical chemoprotection studies with thiols
Clinical chemoprotection studies with thiols
Preclinical studies of dynamic MRI
Clinical imaging studies using ferumoxytol
Delivery of Antihuman African Trypanosomiasis Drugs Across the Blood
Brain and Blood
CSF Barriers
Clinical Presentation of the Disease
Unique Diagnostic Markers
Parasite Resistance: Is Combination Therapy the Way Forward?
BBB Transport of Anti-HAT Drugs
Human BBB characteristics
The ATP-binding cassette family
The solute carrier family
BBB entry of anti-HAT drugs
Latest Research Developments
Delivery of Therapeutic Peptides and Proteins to the CNS
Obstacles to Delivering Protein and Peptides to the CNS
Physicochemical characteristics of the drug
Binding to plasma proteins
Pharmacokinetics of the drug
Brain-to-blood transporters
Enzymatic degradation at the BBB
Saturable Mechanisms of Peptide and Protein Passage Across the BBB
Adsorptive-mediated endocytosis
Receptor-mediated transcytosis
Strategies to Enhance the Delivery of Proteins and Peptides to the CNS
BBB modulation to increase permeability
Physiologically based strategies
Pharmacologically based strategies
Pharmacological Significance of Prostaglandin E2 and D2 Transport at the Brain Barriers
Roles and Kinetics of PGE2 and PGD2 in the CNS
Transporters for PGs and Interspecies Differences
PGE2 Efflux Transport System at the BBB
Effect of cephalosporin antibiotics on PGE2 efflux transport at the BBB
Changes in PGE2 efflux transport at the BBB under inflammatory conditions
PGE2 and PGD2 Efflux Transport Systems at the BCSFB
Drug-PGE2 efflux transport interaction at the BCSFB
PGD2 efflux transport at the BCSFB as a regulatory system for sleep promotion
Steroids and the Blood
Brain Barrier: Therapeutic Implications
Therapeutic targeting of the CNS
Combination Approaches to Attenuate Hemorrhagic Transformation After tPA Thrombolytic Therapy in Patients with Poststroke ...
Increased Hemorrhagic Transformation After tPA Thrombolytic Therapy
Underlying Mechanisms: Multiple Pathological Pathways
DM and Hyperglycemia-Mediated Vascular Pathology
Ischemic Stroke and BBB Disruption
tPA and Extracellular Proteolysis Dysfunction-Mediated BBB Disruption
Multiple Pathological Factors and Interactions
Combination Approaches in Focal Embolic Stroke Model of Hyperglycemia/Diabetic Rats
Aging, the Metabolic Syndrome, and Ischemic Stroke: Redefining the Approach for Studying the Blood
Brain Barrier in a Comp...
Aging, pericytes, and endothelial cells
Age and the Metabolic Syndrome
Cardiovascular disease, aging, and ischemic stroke
Diabetes mellitus type II, aging, and ischemic stroke
Hypertension, aging, and ischemic stroke
Obesity, aging, and stroke
Comorbidities and the BBB
Linking Metabolic Syndrome and Aging
Utilizing animal models to study metabolic syndrome and aging
Drug Abuse and the Neurovascular Unit
Molecular Targets of Common Substances of Abuse
Transport of Drugs of Abuse into the Brain
Regulation of the NVU by Drugs of Abuse
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