Thông tin chi tiết tài liệu

Quốc hội

Thủ tướng Chính phủ

Liên bộ

Danh sách các Bộ, Ngành

Click vào tìm kiếm

Danh sách các tỉnh & thành phố trực thuộc Trung ương

Chi tiết tài liệu

Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders.

Tác giả: Davis, Thomas P.

Chủ đề: Medicine; Pharmacology; Blood Brain Barrier; Blood; CNS Disorders; Brain

Nhà xuất bản: Elsevier

Năm xuất bản: 2014

Loại tài liệu: Book

Mô tả vật lý: 497 p.

Định danh: 978-0-12-800282-7

Ngôn ngữ: en

Đọc trực tuyến

This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Contributions from the best authors in the field; An essential resource for pharmacologists, immunologists, and biochemists.

Cover
Title page
Preface
Contributors
ABC Transporter Regulation by Signaling at the Blood-Brain Barrier: Relevance to Pharmacology
- Introduction
- ABC Transporters at the Blood-Brain Barrier
- ABC Transporter Regulation
  - Regulation of expression
    - Autonomous transcription factors
    - Signaling-activated transcription factors
    - Altered transporter expression in disease
  - Signals that regulate ABC transporter activity
    - Regulation of P-glycoprotein activity through signaling
    - Regulation of P-glycoprotein activity through VEGF signaling
    - Regulation of BCRP activity through estrogen signaling
    - Mechanisms underlying reduced ABC transporter activity
- Acknowledgments
- Conclusion
- References
P-glycoprotein Trafficking as a Therapeutic Target to Optimize CNS Drug Delivery
- Introduction
- Endothelial Cells and the BBB
- The BBB/Neurovascular Unit
- P-glycoprotein
- Transport Across the Brain Barriers
- Drug Delivery to the CNS: Strategies Developed to Circumvent Brain Barrier Sites
- Inhibition of Brain Barrier Efflux Transporters
- Conclusion
- Acknowledgments
- References
Functional Expression of Drug Transporters in Glial Cells: Potential Role on Drug Delivery to the CNS
- Introduction
- Physiological Role of the BBB and Brain Parenchymal Cellular Compartments
- Functional Expression of Drug Transporters in Glial Cells
  - ABC drug efflux transporters
    - P-glycoprotein
    - MDR-associated proteins
    - Breast cancer resistance protein
  - SLC drug transporters
    - Organic anion-transporting polypeptides
      - Human OATP isoforms
      - Rodent OATP isoforms
    - Organic anion transporter family
    - Organic cation transporter systems
      - Organic cation transporters
      - Carnitine/cation transporters
    - Nucleoside membrane transport systems
      - Concentrative nucleoside transporters
      - Equilibrative nucleoside transporters
    - Peptide transporters
    - Monocarboxylate transporters
- Regulation of Drug Transporters in Glial Cells in the Context of Neuropathologies
  - Gliomas
  - Brain HIV-1 infection
  - Epilepsy
  - Parkinson´s disease
  - Alzheimer´s disease
  - Drugs of abuse, analgesics, and anesthetics
- Conclusion
- Acknowledgments
- References
BloodBrain Barrier Na Transporters in Ischemic Stroke
- Introduction
- Ion Transporters and Channels of the BBB
  - Na-K-Cl cotransport of BBB endothelial cells
  - Na/H exchange of BBB endothelial cells
- BBB Na-K-Cl Cotransport and Na/H Exchange in Ischemic Stroke and Cerebral Edema
  - Effects of ischemic factors on BBB Na-K-Cl cotransporter activity
  - In vivo studies: Effects of bumetanide on middle cerebral artery occlusion-induced edema and brain Na uptake
  - Effects of ischemic factors on BBB Na/H exchanger activity
  - In vivo studies: Effects of HOE642 on MCAO-induced edema and brain Na uptake
  - Ischemia-induced BBB endothelial cell swelling: Roles of Na-K-Cl cotransport and Na/H exchange
- Signaling Mechanisms: Roles of AMP Kinase and p38, JNK and ERK MAP Kinases
- Hormonal and Metabolic Factor Effects on BBB Na Transporter Expression and Activities
  - Estradiol effects on CMEC Na transporters
  - Hyperglycemia effects on CMEC Na transporters
- Future Directions
- Acknowledgments
- Conclusion
- References
Transcytosis of Macromolecules at the BloodBrain Barrier
- Introduction
- Endocytosis in Brain Endothelia
- Mechanisms of Macromolecule Transcytosis
- Vesicle Trafficking and Subcellular Localization in Brain Endothelia
- Recycling of Vesicles to Apical or Basolateral Membranes
- Exocytosis in Endothelia
- Targeting Receptor-Mediated Transport for Drug Delivery to Brain
- Conclusion
- References
Drug Delivery to the Ischemic Brain
- Introduction
- Pathophysiology of Ischemia
  - ROS generation
  - Poly(ADP-ribose) polymerase
  - Reperfusion and immune response
  - ROS and changes to the BBB
  - Therapeutic approaches
- Drug Delivery to the Hypoxic/Ischemic Brain
  - Organic anion transporting polypeptides
    - Regulation of Oatp1a4
    - Transporter/substrate interactions at the BBB
  - Nanoparticles
    - Targeting and delivery across the BBB
    - Drug release
- Conclusion
- References
Delivery of Chemotherapeutics Across the BloodBrain Barrier: Challenges and Advances
- Blood-Brain Barrier Disruption
  - Delivering agents across the BBB: Preclinical studies
  - Factors that impact chemotherapy delivery to brain tumors
  - Preclinical BBBD chemotherapy neurotoxicity studies
  - The clinical technique of osmotic BBB opening
  - Safety of BBBD in a multicenter setting
- Introduction
- Primary CNS Lymphoma
  - Development and characterization of a CNS lymphoma rat model
  - mAb delivery and efficacy in the preclinical setting
  - Therapy studies in the rat CNS lymphoma model
  - PCNSL: Clinical studies
  - mAb delivery to brain in the clinical setting
  - Neurocognitive outcomes in long-term PCNSL survivors
  - Anaplastic oligodendroglioma and CNS embryonal tumors: BBBD outcomes
  - CNS metastases
- Chemoprotection Studies
  - Preclinical chemoprotection studies with thiols
  - Clinical chemoprotection studies with thiols
- Advances in Neuroimaging
  - Preclinical studies of dynamic MRI
  - Clinical imaging studies using ferumoxytol
- Conclusion
- Acknowledgments
- References
Delivery of Antihuman African Trypanosomiasis Drugs Across the BloodBrain and BloodCSF Barriers
- Introduction
- A Brief History of HAT
- Clinical Presentation of the Disease
  - T.b. gambiense
  - T.b. rhodesiense
- Unique Diagnostic Markers
  - T.b. gambiense
  - T.b. rhodesiense
- Vector
  - T.b. gambiense
  - T.b. rhodesiense
- Diagnosis of HAT
- Treatment of HAT
  - Pentamidine
  - Melarsoprol
  - Suramin
  - Eflornithine
  - Nifurtimox
- Parasite Resistance: Is Combination Therapy the Way Forward?
- BBB Transport of Anti-HAT Drugs
  - Human BBB characteristics
  - The metabolic barrier
  - The physical barrier
  - The selective barrier
    - The ATP-binding cassette family
    - The solute carrier family
  - BBB entry of anti-HAT drugs
- Latest Research Developments
- Acknowledgments
- Conclusion
- References
Delivery of Therapeutic Peptides and Proteins to the CNS
- Introduction
- Obstacles to Delivering Protein and Peptides to the CNS
  - Barriers of the CNS
  - The BBB
  - Physicochemical characteristics of the drug
  - Binding to plasma proteins
  - Pharmacokinetics of the drug
  - Brain-to-blood transporters
  - Enzymatic degradation at the BBB
- Saturable Mechanisms of Peptide and Protein Passage Across the BBB
  - Transport proteins
  - Adsorptive-mediated endocytosis
  - Receptor-mediated transcytosis
- Strategies to Enhance the Delivery of Proteins and Peptides to the CNS
  - BBB modulation to increase permeability
  - Physiologically based strategies
  - Pharmacologically based strategies
- Acknowledgments
- Conclusion
- References
Pharmacological Significance of Prostaglandin E2 and D2 Transport at the Brain Barriers
- Introduction
- Roles and Kinetics of PGE2 and PGD2 in the CNS
- Transporters for PGs and Interspecies Differences
- PGE2 Efflux Transport System at the BBB
  - Effect of cephalosporin antibiotics on PGE2 efflux transport at the BBB
  - Changes in PGE2 efflux transport at the BBB under inflammatory conditions
- PGE2 and PGD2 Efflux Transport Systems at the BCSFB
  - Drug-PGE2 efflux transport interaction at the BCSFB
  - PGD2 efflux transport at the BCSFB as a regulatory system for sleep promotion
- Conclusion
- Acknowledgments
- References
Steroids and the BloodBrain Barrier: Therapeutic Implications
- Introduction
- Blood-Brain Barrier
  - Tight junctions
  - Transport
  - Pathology
- Steroids and the Brain
  - Neuroactive steroids
  - Therapeutic targeting of the CNS
- Steroid:BBB Interaction
  - Efflux transport
  - Nutrient transport
  - Barrier integrity
  - Other considerations
- Conclusion
- References
Combination Approaches to Attenuate Hemorrhagic Transformation After tPA Thrombolytic Therapy in Patients with Poststroke ...
- Introduction
- Increased Hemorrhagic Transformation After tPA Thrombolytic Therapy
- Underlying Mechanisms: Multiple Pathological Pathways
- DM and Hyperglycemia-Mediated Vascular Pathology
- Ischemic Stroke and BBB Disruption
- tPA and Extracellular Proteolysis Dysfunction-Mediated BBB Disruption
- Multiple Pathological Factors and Interactions
- Combination Approaches in Focal Embolic Stroke Model of Hyperglycemia/Diabetic Rats
- Conclusion
- References
Aging, the Metabolic Syndrome, and Ischemic Stroke: Redefining the Approach for Studying the BloodBrain Barrier in a Comp...
- Introduction
- Cell Aging
  - Aging and astrocytes
  - Aging and microglia
  - Aging, pericytes, and endothelial cells
  - Aging and neurons
- Age and the Metabolic Syndrome
  - Cardiovascular disease, aging, and ischemic stroke
  - Diabetes mellitus type II, aging, and ischemic stroke
  - Hypertension, aging, and ischemic stroke
  - Obesity, aging, and stroke
  - Comorbidities and the BBB
- Linking Metabolic Syndrome and Aging
  - Cerebrovascular disease
  - Glutamate excitotoxicity
  - Utilizing animal models to study metabolic syndrome and aging
  - Oxidative stress
  - ER stress
  - Inflammation
- Conclusion
- References
Drug Abuse and the Neurovascular Unit
- Introduction
- Molecular Targets of Common Substances of Abuse
  - Amphetamines
  - Opioids
  - Alcohol
  - Tobacco (nicotine)
- The Neurovascular Unit
- Transport of Drugs of Abuse into the Brain
  - Opioids
  - Alcohol
  - Amphetamines
  - Nicotine
- Regulation of the NVU by Drugs of Abuse
  - Opioids
  - Amphetamines
  - Alcohol
  - Nicotine
- Conclusion
- References
Index
- A
- B
- C
- D
- E
- F
- G
- H
- I
- J
- L
- M
- N
- O
- P
- R
- S
- T
- V
- W