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Thin calcium phosphate coatings for medical implants

Tác giả: León, Betty; Jansen, John A

Chủ đề:

Chủ đề: Medicine; Coatings; Implants; Thin Calcium Phosphate

Nhà xuất bản: Springer

Năm xuất bản: 2009

Loại tài liệu: Book

Mô tả vật lý: 336 p.

Định danh: 978-0387777184

Ngôn ngữ: en

Đọc trực tuyến

This book presents for the first time, the scattered novel results that have been achieved in very recent years in study on various thin calcium phosphate coatings produced by very diverse techniques. The comparison of thin calcium phosphate coatings with the thick plasma-sprayed ones is also included in the book. Readers will find a comprehensive book reviewing the state-of-the-art of the field with critical assessment of the achievements of the different preparation techniques.

Cover
- Copyright 2009
- Title page
- Preface
- Contents
- Contributors
- List of Abbreviations
Introduction
- 1.1 Plasma-Sprayed Calcium Phosphate Coatings
- 1.2 Clinical Perspective of CaP-Coated Implants
- 1.3 Clinical Concerns About Plasma-Spray CaP Coatings
- 1.4 Future Perspectives of CaP-Coated Implants
- References
Physicochemistry of Apatite and Its Related Calcium Phosphates
- 2.1 Biomaterials for Bone and Teeth Replacement
- 2.2 Properties and Structure of Calcium Phosphate Ceramics
- 2.3 Dissolution and Formation of Calcium Phosphate Crystals
- 2.4 Biological Studies with Calcium Phosphate Bioceramics
- References
Characterization of Thin Calcium Phosphate Coating
- 3.1 Introduction
- 3.2 Infrared Spectroscopy
  - 3.2.1 Application Example
- 3.3 Raman Spectroscopy
  - 3.3.1 Application Example
- 3.4 X-ray Photoelectron Spectroscopy
  - 3.4.1 Qualitatitive and Quantitative XPS
  - 3.4.2 Chemical Shifts
  - 3.4.3 Application Example
  - 3.4.4 Depth Information
- 3.5 Auger Electron Spectroscopy
- 3.6 X-ray Diffraction
  - 3.6.1 Application Example
- 3.7 Electron Microscopy Techniques
  - 3.7.1 Scanning Electron Microscopy
  - 3.7.2 Energy Dispersive X-ray Spectroscopy
  - 3.7.3 Transmission Electron Microscopy
- 3.8 Ion Beam Techniques
  - 3.8.1 Rutherford Back-Scattering Spectrometry
  - 3.8.2 Elastic Recoil Detection
  - 3.8.3 Low Energy Ion Scattering
  - 3.8.4 Proton-Induced X-ray Emission
  - 3.8.5 Secondary Ion Mass Spectrometry
- 3.9 Nuclear Magnetic Resonance
  - 3.9.1 Relevant NMR Basics
  - 3.9.2 Application Examples
    - 3.9.2.1 Characterization of Crystalline CaPs
    - 3.9.2.2 NMR of Plasma-Sprayed Coatings
    - 3.9.2.3 NMR Studies of Nano-crystalline HA and of Bone
  - 3.9.3 Outlook
- 3.10 Mechanical Testing of Thin CaP Coatings
  - 3.10.1 Adhesion Testing
    - 3.10.1.1 Tensile Test
    - 3.10.1.2 Scratch Test
  - 3.10.2 Nanoindentation
References
In Vitro and In Vivo Evaluation of Thin Calcium Phosphate Coatings
- 4.1 Introduction
- 4.2 Development of Bone Under Physiological Conditions Including Various Types of Bone
  - 4.2.1 Enchondral Ossification or Secondary Bone
  - 4.2.2 Intramembranous Ossification, Primary Bone, or Woven Bone
- 4.3 In Vitro Evaluation of CaP Coatings
- 4.4 In Vivo Evaluation of Thin CaP Coatings
- 4.5 Considerations for Predicting Clinical Performance of CaP Coatings
- References
Pulsed Laser Deposition of Thin Calcium Phosphate Coatings
- 5.1 Introduction
- 5.2 Description of the Technique
  - 5.2.1 Mechanism of PLD
    - 5.2.1.1 Interaction Between the Laser and the Calcium Phosphate Target
    - 5.2.1.2 Dynamics of the Ablation Materials (Laser Plume)
- 5.3 Physicochemical Properties of PLD Coatings: Nucleation and Growth on the Substrate
  - 5.3.1 Pressure Dependence
  - 5.3.2 Temperature Dependence
  - 5.3.3 Fluence Dependence
  - 5.3.4 Pulse Repetition Rate Dependence
  - 5.3.5 Preferential Orientation
  - 5.3.6 Influence of the Substrate Material
  - 5.3.7 Interface Between HA and Titanium
  - 5.3.8 Octacalcium Phosphate Thin Films
  - 5.3.9 Deposition on Other Materials
- 5.4 Modifications of the PLD Technique
- 5.5 Mechanical Properties of the PLD Coatings
  - 5.5.1 Adhesive Bond Strength
  - 5.5.2 Scratch Testing
  - 5.5.3 Elastic Modulus and Hardness
- 5.6 In Vitro Evaluation
  - 5.6.1 Dissolution Behavior
  - 5.6.2 Cell Activity
    - 5.6.2.1 PLD Coatings on Titanium Substrates
    - 5.6.2.2 PLD Coatings on Polymer Substrates
- 5.7 Efficacy of PLD Coatings In Vivo
  - 5.7.1 Study in Mongrel Dogs
  - 5.7.2 Study in Rats
  - 5.7.3 Studies in Minipigs
  - 5.7.4 Studies in Rabbits
  - 5.7.5 Studies in Beagle Dogs
- 5.8 Conclusions and Prospects for Applications
- References
Ion Beam Techniques for Thin Calcium Phosphate Coating Production
- 6.1 Introduction
- 6.2 Ion Beam Technique
- 6.3 Coating Characterization
- 6.4 Mechanical Properties of Thin Coatings (Composites with Ceramics and Metals)
- 6.5 Change in Bond Strength and Solubility by Heat Treatment
- 6.6 Biological Responses
  - 6.6.1 In Vitro Cell Behavior of Thin CaP Coatings
  - 6.6.2 In Vivo Bone Behavior of Thin CaP Coatings
  - 6.6.3 Immobilization of Bisphosphonates Through Thin CaP Coatings
- 6.7 Critical Assessment of Prospective Use
- Appendix: Significant references for this chapter
- References
Calcium Phosphate Coating Produced by a Sputter Deposition Process
- 7.1 Introduction
- 7.2 Sputtering Technique
- 7.3 Physicochemical Properties of Sputtered Coatings
- 7.4 Dissolution
- 7.5 In Vitro and In Vivo Biological Evaluation
  - 7.5.1 In Vitro Study
  - 7.5.2 In Vivo Study
- 7.6 Conclusion
- References
Silicon-Substituted Hydroxyapatite Thin Films
- 8.1 Introduction
- 8.2 Production of SiHA Coatings
- 8.3 Physicochemical Characterization of SiHA Coating
- 8.4 In Vitro Study: Acellular Simulated Body Fluid
- 8.5 In Vitro Cell Culture
- 8.6 Conclusion
- References
Electrochemically Assisted Deposition of Thin CaP Coatings
- 9.1 Introduction
  - 9.1.4 Advantages of the ECAD Method
  - 9.1.4 Disadvantages of the ECAD Method
- 9.2 ECAD: The Technique
  - 9.2.1 Basic Principles
  - 9.2.2 Influence of Processing Conditions on Coating Properties
    - 9.2.2.1 Influence on Coating Composition
    - 9.2.2.2 Influence on Coating Mass
  - 9.2.3 Influence of Electrochemical and Solution Parameters
    - 9.2.3.1 Processing with Constant Cell Voltage
    - 9.2.3.2 Potentiostatic Processing
    - 9.2.3.3 Galvanostatic Processing
    - 9.2.3.4 Summary
  - 9.2.4 Formation of Composite Coatings
    - 9.2.4.1 Composite Coatings with Inorganic Additives
    - 9.2.4.2 Composite Coatings with Organic Additives
    - 9.2.4.3 Summary
  - 9.2.5 Basic Principles of the Electrophoretic Deposition Process
- 9.3 Physicochemical Properties of Thin Coatings
- 9.4 Mechanical Properties of Thin Coatings
- 9.5 Similarities and Differences Between Plasma-Sprayed HA and Thin CaP Coating
- 9.6 Physicochemical Stability In Vitro and In Vivo
- 9.7 Biological Efficiency of the Thin CaP Coating
  - 9.7.1 Cell Culture Investigations Using ECAD-CPP Coating
  - 9.7.2 Animal Experimental Investigations
  - 9.7.3 Experience from Clinical Applications
  - 9.7.4 Summary
- 9.8 Characterization of Thin CaP Coating in Relation to the Regulatory Pathway
- 9.9 Critical Assessment on the Prospects of Future Industrial Applications (Advantages and Difficulties)
- References
Electrosprayed Calcium Phosphate Coating for Biomedical Purposes
- 10.1 Introduction to Electrostatic Spray Deposition
- 10.2 Electrospraying
  - 10.2.1 Conventional Spraying
  - 10.2.2 Electrospraying
- 10.3 Physicochemical Properties of Electrosprayed CaP Coatings
  - 10.3.1 Chemical Properties of Electrosprayed Coatings
    - 10.3.1.1 Influence of Precursor Solution Parameters on Chemical Properties
    - 10.3.1.2 Influence of Physical, Apparatus-Related Parameters on Chemical Properties
  - 10.3.2 Morphological Properties of Electrosprayed Coatings
    - 10.3.2.1 Influence of Physical, Apparatus-Related Parameters on Morphological Properties
    - 10.3.2.2 Influence of Chemical, Precursor Solution Parameters on Morphological Properties
  - 10.3.3 Conclusion
- 10.4 Mechanical Properties of Porous, Electrosprayed CaP Coatings
  - 10.4.1 Fatigue Testing
  - 10.4.2 Scratch Testing
  - 10.4.3 Explantation of Dental Screw Implants
  - 10.4.4 Conclusion
- 10.5 Similarities and Differences Between Plasma-Sprayed and Electrosprayed CaP Coatings
- 10.6 Physicochemical Stability In Vitro and In Vivo
  - 10.6.1 In Vitro Soaking in Simulated Body Fluid
  - 10.6.2 In Vivo Subcutaneous Implantation
  - 10.6.3 Comparison Between In Vitro and In Vivo Studies
  - 10.6.4 Conclusion
- 10.7 Efficacy of Porous, Electrosprayed CaP Coatings In Vivo
  - 10.7.1 Implant Materials, Surgical Procedure, Implant Retrieval
  - 10.7.2 Histological Evaluation
  - 10.7.3 Histomorphometric Analysis
  - 10.7.4 Discussion
  - 10.7.5 Conclusion
- 10.8 Prospects of Future Industrial Applications
- References
Biomimetic Coatings and Their Biological Functionalization
- 11.1 Introduction
- 11.2 Biomimetic Coatings
  - 11.2.1 Biomimetic Coating Techniques
  - 11.2.2 Characterization of Coatings
  - 11.2.3 Typical Results Obtained Using the Standard Biomimetic Coating Process
  - 11.2.4 Incorporation of Osteogenic Agents into Biomimetic Coatings: Biological Functionalization
- 11.3 Biomimetic CaP Coatings as a Delivery Vehicle for Osteogenic Drugs
  - 11.3.1 In-Vitro Testing of the Osteogenic Potential of Biomimetic Coatings Bearing BMP-2
  - 11.3.2 In-Vivo Testing of the Osteogenic Potential of Biomimetic Coatings Bearing BMP-2
    - 11.3.2.1 Ectopic Ossification Model in Rats
    - 11.3.2.2 Orthotopic Ossification Model in Miniature Pigs
- 11.4 Biologically Functionalized Biomimetic Coatings
- 11.5 Conclusions
- References
Index